Title : Inhibition by mepacrine and amylase secretion from intact and permeabilized rat pancreatic acini.

Pub. Date : 1992 Apr 15

PMID : 1373616






2 Functional Relationships(s)
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1 In intact rat pancreatic acini, the phospholipase A2 inhibitor mepacrine did not affect basal amylase release but dose-dependently inhibited the carbachol (IC50 65 microM) and CCK-8 (IC50 210 microM)-stimulated amylase release. Sincalide phospholipase A2 group IB Rattus norvegicus
2 From these results we conclude that carbachol, CCK-8 and GTPrS probably activate a phospholipase A2 closely coupled to exocytosis. Sincalide phospholipase A2 group IB Rattus norvegicus