Pub. Date : 1992 Feb
PMID : 1371688
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bleomycin treatment of rat lung fibroblast cultures resulted in an increase of total cellular transforming growth factor-beta (TGF-beta) mRNA and increased secretion of TGF-beta protein into the conditioned media. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | Bleomycin treatment of rat lung fibroblast cultures resulted in an increase of total cellular transforming growth factor-beta (TGF-beta) mRNA and increased secretion of TGF-beta protein into the conditioned media. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | The bleomycin-induced increase of TGF-beta mRNA was decreased by cells cultured in the presence of either cycloheximide, an inhibitor of protein synthesis, or 2-mercapto-1-(beta-4-pyridethyl) benzimidazole, an inhibitor of RNA synthesis. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | Transcription of TGF-beta mRNA was increased 12 h after bleomycin treatment, whereas the transcription of type I procollagen, type III procollagen, and beta-actin mRNAs were increased after 48 h of bleomycin treatment. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |
| 5 | These results suggest bleomycin regulation of TGF-beta at both the mRNA and protein levels. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |
| 6 | Following bleomycin treatment, TGF-beta mRNA was shown to be located more prominently in those fibroblasts that contain primarily collagen type I mRNAs. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |