Title : Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation.

Pub. Date : 2003 Sep 30

PMID : 13679577






1 Functional Relationships(s)
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1 In addition, the signal to FKHR degradation from insulin is mediated by the phosphatidylinositol 3-kinase pathway, and the mutation of FKHR at the serine or threonine residues phosphorylated by protein kinase B, a downstream target of phosphatidylinositol 3-kinase, inhibits the ubiquitination in vivo and in vitro. Threonine insulin Homo sapiens