Title : The combi-targeting concept: chemical dissection of the dual targeting properties of a series of "combi-triazenes".

Pub. Date : 2003 Sep 25

PMID : 13678409






1 Functional Relationships(s)
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1 Here, we report a structure-function approach whereby a series of quinazoline-based "combi-triazenes" were altered to either abrogate the affinity of the EGFR-targeting quinazoline head or to suppress the DNA-damaging property of the triazene tail. Triazenes epidermal growth factor receptor Mus musculus