Title : Prothrombin Salakta: substitution of glutamic acid-466 by alanine reduces the fibrinogen clotting activity and the esterase activity.

Pub. Date : 1992 Aug 25

PMID : 1354985






2 Functional Relationships(s)
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1 The model building and the molecular dynamics simulation of thrombin Salakta suggest that the Glu-466----Ala substitution would change the proper conformation around the substrate binding site containing Trp-468, which is a unique surface loop on the thrombin molecule. Tryptophan coagulation factor II, thrombin Homo sapiens
2 The model building and the molecular dynamics simulation of thrombin Salakta suggest that the Glu-466----Ala substitution would change the proper conformation around the substrate binding site containing Trp-468, which is a unique surface loop on the thrombin molecule. Tryptophan coagulation factor II, thrombin Homo sapiens