Pub. Date : 1992 Jul
PMID : 1353743
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation. | Aminosalicylic Acid | interleukin 1 alpha | Homo sapiens |
| 2 | Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation. | Aminosalicylic Acid | interleukin 1 alpha | Homo sapiens |
| 3 | Three weeks of treatment with 5-ASA or 4-ASA (50 micrograms/kg) and one week of treatment with 5-ASA significantly decreased colonic interleukin-1 generation and the extent and severity of inflammation in a rat model of colitis induced by trinitrobenzene sulphonic acid. | Aminosalicylic Acid | interleukin 1 alpha | Homo sapiens |
| 4 | Three weeks of treatment with 5-ASA or 4-ASA (50 micrograms/kg) and one week of treatment with 5-ASA significantly decreased colonic interleukin-1 generation and the extent and severity of inflammation in a rat model of colitis induced by trinitrobenzene sulphonic acid. | Aminosalicylic Acid | interleukin 1 alpha | Homo sapiens |
| 5 | Three weeks of treatment with 5-ASA or 4-ASA (50 micrograms/kg) and one week of treatment with 5-ASA significantly decreased colonic interleukin-1 generation and the extent and severity of inflammation in a rat model of colitis induced by trinitrobenzene sulphonic acid. | Aminosalicylic Acid | interleukin 1 alpha | Homo sapiens |
| 6 | Interleukin-1 content in tissue cultured in the presence of 5-ASA (100 micrograms/ml) was two-thirds of its content in tissue cultured in drug free medium and its release into the medium was decreased by 50%. | Aminosalicylic Acid | interleukin 1 alpha | Homo sapiens |
| 7 | We conclude that pharmacological suppression of colonic interleukin-1 generation may be one, although not the sole mechanism to explain the therapeutic efficacy of 5-ASA in the treatment of inflammatory bowel disease. | Aminosalicylic Acid | interleukin 1 alpha | Homo sapiens |