Title : Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation.

Pub. Date : 1992 Jul

PMID : 1353743






7 Functional Relationships(s)
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1 Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation. Aminosalicylic Acid interleukin 1 alpha Homo sapiens
2 Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation. Aminosalicylic Acid interleukin 1 alpha Homo sapiens
3 Three weeks of treatment with 5-ASA or 4-ASA (50 micrograms/kg) and one week of treatment with 5-ASA significantly decreased colonic interleukin-1 generation and the extent and severity of inflammation in a rat model of colitis induced by trinitrobenzene sulphonic acid. Aminosalicylic Acid interleukin 1 alpha Homo sapiens
4 Three weeks of treatment with 5-ASA or 4-ASA (50 micrograms/kg) and one week of treatment with 5-ASA significantly decreased colonic interleukin-1 generation and the extent and severity of inflammation in a rat model of colitis induced by trinitrobenzene sulphonic acid. Aminosalicylic Acid interleukin 1 alpha Homo sapiens
5 Three weeks of treatment with 5-ASA or 4-ASA (50 micrograms/kg) and one week of treatment with 5-ASA significantly decreased colonic interleukin-1 generation and the extent and severity of inflammation in a rat model of colitis induced by trinitrobenzene sulphonic acid. Aminosalicylic Acid interleukin 1 alpha Homo sapiens
6 Interleukin-1 content in tissue cultured in the presence of 5-ASA (100 micrograms/ml) was two-thirds of its content in tissue cultured in drug free medium and its release into the medium was decreased by 50%. Aminosalicylic Acid interleukin 1 alpha Homo sapiens
7 We conclude that pharmacological suppression of colonic interleukin-1 generation may be one, although not the sole mechanism to explain the therapeutic efficacy of 5-ASA in the treatment of inflammatory bowel disease. Aminosalicylic Acid interleukin 1 alpha Homo sapiens