Title : Effects of reserpine on tyrosine hydroxylase mRNA levels in locus coeruleus and medullary A1 and A2 neurons analyzed by in situ hybridization histochemistry and quantitative image analysis methods.

Pub. Date : 1992 Apr

PMID : 1350653






4 Functional Relationships(s)
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1 Effects of reserpine on tyrosine hydroxylase mRNA levels in locus coeruleus and medullary A1 and A2 neurons analyzed by in situ hybridization histochemistry and quantitative image analysis methods. Reserpine tyrosine hydroxylase Homo sapiens
2 This reserpine-induced depletion of NE was accompanied by a 2- to 3-fold increase in TH mRNA levels in LC and A1 neurons but no change in message levels occurred in A2 cells 24 h after reserpine. Reserpine tyrosine hydroxylase Homo sapiens
3 TH mRNA levels 72 h after reserpine did not differ from 48 h values in A1, A2 and LC neurons. Reserpine tyrosine hydroxylase Homo sapiens
4 Thus, TH gene expression in A1 neurons increases after reserpine treatment in a manner equivalent to that observed in LC, adrenal medulla and superior cervical ganglia. Reserpine tyrosine hydroxylase Homo sapiens