Title : Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts.

Pub. Date : 1992 May 25

PMID : 1350280






2 Functional Relationships(s)
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1 Cytoplasts from P-glycoprotein containing multidrug-resistant K562 cells demonstrated a verapamil-reversible, decreased daunorubicin accumulation that was observed in resistant whole cells. Daunorubicin ATP binding cassette subfamily B member 1 Homo sapiens
2 Parental K562 cells and cytoplasts exhibit an energy-dependent accumulation of daunorubicin into cytoplasmic organelles that is also present in resistant cells and cytoplasts when P-glycoprotein mediated efflux is inhibited. Daunorubicin ATP binding cassette subfamily B member 1 Homo sapiens