Pub. Date : 1992 Mar 5
PMID : 1347041
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Two ATP-binding domains are found in members of the family of ATP-dependent transport proteins, which includes P-glycoprotein and cystic fibrosis transmembrane conductance regulator. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Two ATP-binding domains are found in members of the family of ATP-dependent transport proteins, which includes P-glycoprotein and cystic fibrosis transmembrane conductance regulator. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | To investigate the involvement of the two ATP-binding domains in the ATPase activity of P-glycoprotein, full-length and the 5"-half of human MDR1 cDNA, which encodes P-glycoprotein, were fused with the Escherichia coli lacZ gene and expressed in NIH3T3 cells. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | To investigate the involvement of the two ATP-binding domains in the ATPase activity of P-glycoprotein, full-length and the 5"-half of human MDR1 cDNA, which encodes P-glycoprotein, were fused with the Escherichia coli lacZ gene and expressed in NIH3T3 cells. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Immunoprecipitated full-length P-glycoprotein beta-galactosidase showed ATPase activity with apparent specific activity of 180 nmol/mg/min, a value higher than previously reported, in the presence of phospholipids, suggesting that stabilization of the transmembrane domains is necessary for ATP hydrolysis. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | N-terminal half P-glycoprotein-beta-galactosidase also showed ability to hydrolyze ATP but with slightly lower specific activity. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |