Title : Calcium ionophore treatment impairs the sterol-mediated suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, and farnesyl diphosphate synthetase.

Pub. Date : 1992 Feb 5

PMID : 1346397






1 Functional Relationships(s)
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1 Surprisingly, the addition of A23187 to THP-1 cells incubated in the presence of 25-hydroxycholesterol and mevalonic acid also led to significant increases in the mRNA levels for HMG-CoA reductase and HMG-CoA synthase. 25-hydroxycholesterol 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens