Title : Fidelity of replication of the leading and the lagging DNA strands opposite N-methyl-N-nitrosourea-induced DNA damage in human cells.

Pub. Date : 1992 Dec 25

PMID : 1336179






1 Functional Relationships(s)
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1 To test whether the different fidelity of DNA polymerases synthesizing the leading and the lagging strands might contribute to MNU-induced mutation distribution the mutagenesis study was repeated on the shuttle vector pTF-EBV which contains the gpt gene in the inverted orientation. Methylnitrosourea glutamic--pyruvic transaminase Homo sapiens