Title : Pertussis toxin sensitive G-protein coupling of HDL receptor to phospholipase C in human platelets.

Pub. Date : 1992 Sep 1

PMID : 1333103






3 Functional Relationships(s)
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1 Initially we established that, in human platelets, low concentrations of HDL3 stimulate phosphatidylcholine (PC) hydrolysis and a transient increase in 1,2-diacylglycerol (DAG). Phosphatidylcholines HDL3 Homo sapiens
2 Initially we established that, in human platelets, low concentrations of HDL3 stimulate phosphatidylcholine (PC) hydrolysis and a transient increase in 1,2-diacylglycerol (DAG). Phosphatidylcholines HDL3 Homo sapiens
3 In (3H) PC prelabelled platelets, phosphocholine is released into the medium during HDL3 induced PC turnover with a 1.5 to 2 fold increment, indicating that HDL3 stimulated DAG generation in platelets is likely due to phospholipase C (PLC). Phosphatidylcholines HDL3 Homo sapiens