Title : The reduction of cytochrome b558 and the activity of the respiratory burst oxidase from human neutrophils.

Pub. Date : 1992 Dec 5

PMID : 1332956






2 Functional Relationships(s)
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1 We have confirmed the partial reduction of cytochrome b558 in neutrophil cytoplasts and in oxidase preparations exposed to NADPH, but have found that the reduction of the cytochrome bears no apparent relation to the activity of the oxidase, and can occur when NADPH is added to neutrophil membrane preparations that are unable to manufacture O2-. NADP mitochondrially encoded cytochrome b Homo sapiens
2 We therefore conclude that the NADPH-dependent reduction of cytochrome b558 seen in these preparations is unlikely to be a reflection of a catalysis-related steady state and that inferences drawn from such observations regarding the kinetic competence of the cytochrome may need to be reconsidered. NADP mitochondrially encoded cytochrome b Homo sapiens