Title : p53 gene mutation spectrum in hepatocellular carcinoma.

Pub. Date : 1992 Nov 15

PMID : 1330291






1 Functional Relationships(s)
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1 In order to clarify the significance of mutation of the p53 tumor suppressor gene in the genesis and development of human hepatocellular carcinoma (HCC) in an aflatoxin B1 low-exposure area, the spectrum, i.e., incidence, type, and site, of p53 gene mutations was examined in 169 tissue samples resected mainly from Japanese patients using single-strand conformation polymorphism analysis and direct sequencing. Aflatoxin B1 tumor protein p53 Homo sapiens