Title : Prolonged activation of inhibitory somatostatin receptors increases adenylate cyclase activity in wild-type and Gs alpha-deficient (cyc-) S49 mouse lymphoma cells.

Pub. Date : 1992 Sep

PMID : 1329904






3 Functional Relationships(s)
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1 After incubation with SMS for 24 h, the forskolin-stimulated cAMP synthetic rate in intact cyc- cells was increased by 76%, similar to the increase found in the wild-type cells. Colforsin peptidylprolyl isomerase A, pseudogene 1 Mus musculus
2 Forskolin-stimulated adenylate cyclase activity in the presence of Mn2+ was also increased in membranes prepared from SMS-treated cyc- cells; however, guanine nucleotide-mediated inhibition of adenylate cyclase activity was not changed despite a small decrease in inhibitory Gi alpha subunits detected by immunoblotting. Colforsin peptidylprolyl isomerase A, pseudogene 1 Mus musculus
3 Pretreatment of cyc- cells with pertussis toxin prevented SMS from inducing the enhancement of forskolin-stimulated cAMP accumulation in intact cells. Colforsin peptidylprolyl isomerase A, pseudogene 1 Mus musculus