Title : Biological activity and metabolism of 20-hydroxyeicosatetraenoic acid in the human platelet.

Pub. Date : 1992 Jun

PMID : 1327375






2 Functional Relationships(s)
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1 The cytochrome P-450 metabolite of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE), was found to be a potent, dose-dependent inhibitor of platelet aggregation and inhibitor of thromboxane biosynthesis induced by arachidonic acid (IC50 5.2 +/- 1.5 microM), A23187 (IC50 16.2 +/- 5.4 microM), and U46619 (IC50 7.8 +/- 2.4 microM). 20-hydroxy-5,8,11,14-eicosatetraenoic acid cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 The cytochrome P-450 metabolite of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE), was found to be a potent, dose-dependent inhibitor of platelet aggregation and inhibitor of thromboxane biosynthesis induced by arachidonic acid (IC50 5.2 +/- 1.5 microM), A23187 (IC50 16.2 +/- 5.4 microM), and U46619 (IC50 7.8 +/- 2.4 microM). 20-hydroxy-5,8,11,14-eicosatetraenoic acid cytochrome P450 family 4 subfamily F member 3 Homo sapiens