Title : Retinoic acid and phorbol ester synergistically up-regulate IL-8 expression and specifically modulate protein kinase C-epsilon in human skin fibroblasts.

Pub. Date : 1992 Aug 15

PMID : 1323613






2 Functional Relationships(s)
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1 Induction of IL-8 by TPA was blocked by 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine, which inhibits PKC and cAMP-dependent protein kinases (PKA), but not by N-(2-ganidinoethyl)-5-isoquinoline sulfonamide, which preferentially inhibits PKA, consistent with the participation of PKC in the induction of IL-8 by TPA. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine C-X-C motif chemokine ligand 8 Homo sapiens
2 Induction of IL-8 by TPA was blocked by 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine, which inhibits PKC and cAMP-dependent protein kinases (PKA), but not by N-(2-ganidinoethyl)-5-isoquinoline sulfonamide, which preferentially inhibits PKA, consistent with the participation of PKC in the induction of IL-8 by TPA. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine C-X-C motif chemokine ligand 8 Homo sapiens