Title : Rapid desensitization of vasopressin-stimulated phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine hydrolysis questions the role of these pathways in sustained diacylglycerol formation in A10 vascular-smooth-muscle cells.

Pub. Date : 1992 Aug 1

PMID : 1323272






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Vasopressin stimulated sustained accumulation of total [3H]inositol phosphates ([3H]IP) in the presence of Li+; however, this was significantly decreased by adding a vasopressin-receptor antagonist at different times after initial stimulation. Tritium arginine vasopressin Homo sapiens
2 Vasopressin stimulated sustained accumulation of total [3H]inositol phosphates ([3H]IP) in the presence of Li+; however, this was significantly decreased by adding a vasopressin-receptor antagonist at different times after initial stimulation. Tritium arginine vasopressin Homo sapiens
3 This coincided with an enhancement of vasopressin-stimulated [3H]IP accumulation. Tritium arginine vasopressin Homo sapiens
4 In cells exposed to the V1a-receptor antagonist 5 min after addition of vasopressin, subsequent DAG formation was significantly decreased, indicating that sustained formation of DAG, like [3H]IP accumulation, was dependent on continual agonist receptor activation. Tritium arginine vasopressin Homo sapiens