Title : Thrombin and histamine rapidly stimulate the phosphorylation of the myristoylated alanine-rich C-kinase substrate in human umbilical vein endothelial cells: evidence for distinct patterns of protein kinase activation.

Pub. Date : 1992 Jul

PMID : 1320036






3 Functional Relationships(s)
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1 One micromolar histamine, like alpha-thrombin, produces sustained phosphorylation of MARCKS (plateau 3-5 min). Histamine coagulation factor II, thrombin Homo sapiens
2 HUVEC treated with 100 microM histamine for 5 min can be restimulated by alpha-thrombin but not fresh histamine, suggesting that the histamine receptor was desensitized. Histamine coagulation factor II, thrombin Homo sapiens
3 MARCKS phosphorylation can also be induced by several exogenous protein kinase C (PKC) activators and both alpha-thrombin- and histamine-induced MARCKS phosphorylation are inhibited by the PKC antagonist staurosporine. Histamine coagulation factor II, thrombin Homo sapiens