Pub. Date : 1992 May
PMID : 1319843
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We demonstrate that disruption of PDR5 causes marked hypersensitivity not only to cycloheximide but also to sulphometuron methyl and the mitochondrial inhibitors chloramphenicol, lincomycin, erythromycin and antimycin. | Cycloheximide | ATP-binding cassette multidrug transporter PDR5 | Saccharomyces cerevisiae S288C |
| 2 | Genetic analysis of double mutants containing an insertion in PDR5 (pdr5:Tn5), which renders cells hypersensitive to cycloheximide, and a pdr1 mutation, which confers resistance to this inhibitor, indicates that the expression of resistance requires a functional PDR5 gene. | Cycloheximide | ATP-binding cassette multidrug transporter PDR5 | Saccharomyces cerevisiae S288C |
| 3 | Genetic analysis of double mutants containing an insertion in PDR5 (pdr5:Tn5), which renders cells hypersensitive to cycloheximide, and a pdr1 mutation, which confers resistance to this inhibitor, indicates that the expression of resistance requires a functional PDR5 gene. | Cycloheximide | ATP-binding cassette multidrug transporter PDR5 | Saccharomyces cerevisiae S288C |