Title : The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity.

Pub. Date : 1992 Jun 5

PMID : 1317850






1 Functional Relationships(s)
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1 Hirugen was a competitive inhibitor for either GF1-6 or GF2.5-6 stimulation of thrombin activation of protein C. GF5-6, which binds to thrombin without altering its ability to activate protein C, competed with fluorescein-labeled Hirugen for binding to thrombin. Fluorescein coagulation factor II, thrombin Homo sapiens