Title : Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

Pub. Date : 1992 Apr 15

PMID : 1314112






1 Functional Relationships(s)
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1 In this model of PLD activation, alpha-thrombin receptor occupancy leads to the breakdown of phosphatidylinositol 4,5-bisphosphate catalyzed by phospholipase C producing the Ca2+ secretagogue IP3 and DAG. Phosphatidylinositol 4,5-Diphosphate coagulation factor II, thrombin Homo sapiens