Title : Generation of free radicals during the reductive metabolism of nilutamide by lung microsomes: possible role in the development of lung lesions in patients treated with this anti-androgen.

Pub. Date : 1992 Feb 4

PMID : 1311586






1 Functional Relationships(s)
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1 The steady state concentration of this radical was not decreased by CO or SKF 525-A (two inhibitors of cytochrome P450), but was decreased by NADP+ (10 mM) or p-chloromercuribenzoate (0.47 mM) (two inhibitors of NADPH-cytochrome P450 reductase activity). NADP cytochrome p450 oxidoreductase Rattus norvegicus