Title : Site-directed mutagenesis in rat liver 6-phosphofructo-2-kinase. Mutation at the fructose 6-phosphate binding site affects phosphate activation.

Pub. Date : 1992 Mar 5

PMID : 1311308






1 Functional Relationships(s)
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1 To identify those residues involved in fructose 6-phosphate binding to the kinase domain of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase site-directed mutations were engineered at Lys194, Arg195, Arg230, and Arg238. fructose-6-phosphate 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Rattus norvegicus