Title : Regulation of purine nucleotide synthesis in human B lymphoblasts with both hypoxanthine-guanine phosphoribosyltransferase deficiency and phosphoribosylpyrophosphate synthetase superactivity.

Pub. Date : 1992 Mar 5

PMID : 1311306






1 Functional Relationships(s)
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Protein Name
Organism
1 Insufficient generation of IMP (and ultimately guanylates) to support growth of lymphoblasts lacking HGPRT activity and blocked in purine synthesis de novo best explained these findings, implying that a major route of interconversion of AMP to IMP involves the reaction sequence: AMP----Ado----Ino----Hyp----IMP. Inosine Monophosphate hypoxanthine phosphoribosyltransferase 1 Homo sapiens