Pub. Date : 1992 Jan 1
PMID : 1309423
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EC significantly blocked the thrombin stimulated breakdown of phosphatidylinositol-4,5-bisphosphate (PIP2) and the production of phosphatidic acid in [32P]orthophosphate-labeled platelets and of inositol trisphosphate in [3H]myoinositol-labeled platelets. | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |
| 2 | EC significantly blocked the thrombin stimulated breakdown of phosphatidylinositol-4,5-bisphosphate (PIP2) and the production of phosphatidic acid in [32P]orthophosphate-labeled platelets and of inositol trisphosphate in [3H]myoinositol-labeled platelets. | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |
| 3 | These data indicate that EDRF blocks thrombin-induced platelet aggregation by inhibiting the activation of PIP2-specific phospholipase C and thereby suppressing the consequent activation of PKC and the mobilization of [Ca2+]i. | Phosphatidylinositol 4,5-Diphosphate | coagulation factor II, thrombin | Homo sapiens |