Title : Increased excretion of leukotriene E4 during aspirin-induced asthma.

Pub. Date : 1992 Jan

PMID : 1309376






1 Functional Relationships(s)
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1 The etiology of aspirin-sensitive asthma is unknown, but a plausible hypothesis is that the inhibitory effect of aspirin on the cyclooxygenase enzyme increases formation of bronchoconstrictor leukotrienes via "shunting" of unmetabolized arachidonic acid into metabolism by the 5-lipoxygenase enzyme. Aspirin arachidonate 5-lipoxygenase Homo sapiens