Title : Mechanism and epidemiology of bone effects of cadmium.

Pub. Date : 1992

PMID : 1303956






1 Functional Relationships(s)
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1 Six possible mechanisms may explain the cadmium-induced bone effects: (1) interference with parathyroid hormone (PTH) stimulation of vitamin D production in kidney cells; (2) reduced activity of kidney enzymes activating vitamin D; (3) increased excretion of calcium in urine; (4) reduced absorption of calcium from intestines; (5) direct interference with calcium incorporation into bone cells; and (6) direct interference with collagen production in bone cells. Vitamin D parathyroid hormone Homo sapiens