Pub. Date : 2003 Sep 23
PMID : 12972295
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To investigate histamine effects in H2-R-transfected rat atrial myocytes, endogenous GIRK currents and L-type Ca2+ currents were used as functional assays. | Histamine | histamine receptor H 2 | Rattus norvegicus |
| 2 | In H2-R-overexpressing cells, histamine activated IK(ACh) via Gs-derived betagamma subunits since the histamine-induced current was insensitive to pertussis toxin. | Histamine | histamine receptor H 2 | Rattus norvegicus |
| 3 | When IK(ACh) was maximally activated by GTP-gamma-S, histamine induced an irreversible inhibition of the inward current in a fraction of H2-R-transfected cells. | Histamine | histamine receptor H 2 | Rattus norvegicus |