Pub. Date : 2003 Sep
PMID : 12966366
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, ex vivo COX-1-dependent thromboxane B(2) synthesis was inhibited significantly less by aceclofenac than by diclofenac. | aceclofenac | mitochondrially encoded cytochrome c oxidase I | Homo sapiens |
| 2 | Although 100 mg aceclofenac yielded diclofenac concentrations substantially lower than 75 mg diclofenac, these were sufficient for a sustained block of COX-2 but caused a minor and shorter inhibition of COX-1 than 75 mg diclofenac. | aceclofenac | mitochondrially encoded cytochrome c oxidase I | Homo sapiens |
| 3 | In conclusion, both COX-1-sparing and COX-2-inhibitory actions of aceclofenac may rest in its limited but sustained biotransformation to diclofenac. | aceclofenac | mitochondrially encoded cytochrome c oxidase I | Homo sapiens |