Title : Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.

Pub. Date : 2003 Oct

PMID : 12961066






1 Functional Relationships(s)
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1 RESULTS: In HEK 293 cells, NNC 55-0118 and NN414 activated Kir6.2/SUR1 currents with EC(50) values of 0.33 micromol/l and 0.45 micromol/l, respectively, compared with that of 31 micro mol/l for diazoxide. Diazoxide potassium inwardly rectifying channel subfamily J member 11 Homo sapiens