Title : Inhibition of angiogenesis by non-toxic doses of temozolomide.

Pub. Date : 2003 Aug

PMID : 12960735






1 Functional Relationships(s)
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1 For the inhibition of basic fibroblast growth factor (bFGF)-, vascular endothelial growth factor (VEGF)- or beta-phorbol 12-myristate-13-acetate (PMA)-induced endothelial cell proliferation or endothelial cell adhesion to fibronectin, TMZ concentrations of at least 25 microM were necessary, indicating that bFGF-, VEGF- or protein kinase C-mediated pathways may not primarily be involved in the observed antiangiogenic effect. Tetradecanoylphorbol Acetate fibronectin 1 Homo sapiens