Title : Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa.

Pub. Date : 2003 Sep 16

PMID : 12960371






2 Functional Relationships(s)
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1 In the present study, we have examined whether inhibition of COX-2 activity in healthy volunteers taking aspirin exacerbates gastric mucosal injury and if such an effect would be prevented by NCX-4016, a NO-releasing derivative of aspirin. Aspirin T cell leukemia homeobox 2 Homo sapiens
2 The mean mucosal injury score was 5.8 +/- 1.8 in subjects treated with aspirin and 2.4 +/- 0.7 (P < 0.01 vs. aspirin) in subjects treated with NCX-4016. Aspirin T cell leukemia homeobox 2 Homo sapiens