Title : Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement.

Pub. Date : 2003 Sep

PMID : 12949730






2 Functional Relationships(s)
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1 Bid was required for permeability transition and mitochondria depolarization in addition to the previously defined release of cytochrome c. Permeability transition inhibitors cyclosporin A and aristolochic acid could inhibit mitochondria activation effectively, but not as much as the deletion of the bid gene, and they could not inhibit Bak oligomerization. Cyclosporine BH3 interacting domain death agonist Mus musculus
2 Bid was required for permeability transition and mitochondria depolarization in addition to the previously defined release of cytochrome c. Permeability transition inhibitors cyclosporin A and aristolochic acid could inhibit mitochondria activation effectively, but not as much as the deletion of the bid gene, and they could not inhibit Bak oligomerization. Cyclosporine BH3 interacting domain death agonist Mus musculus