Pub. Date : 2003 Nov 7
PMID : 12941938
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | 3-MC induced CYP1A1 in H4IIE cells in a time- and concentration-dependent manner. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | Oltipraz (10 microM) significantly inhibited CYP1A1 and CYP1A1-luciferase gene induction by 3-MC with no increase in AhR DNA binding. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | Oltipraz (10 microM) significantly inhibited CYP1A1 and CYP1A1-luciferase gene induction by 3-MC with no increase in AhR DNA binding. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | Overexpression of dominant-negative mutant C/EBP significantly abolished the ability of oltipraz to suppress 3-MC-inducible CYP1A1 and the CYP1A1 reporter gene expression. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 6 | Consistently, C/EBPbeta overexpression blocked CYP1A1 reporter gene induction by 3-MC. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 7 | These results provide evidence that oltipraz suppresses 3-MC induction of CYP1A1 gene expression and that activation of C/EBPbeta by oltipraz contributes to suppression of 3-MC-inducible AhR-mediated CYP1A1 expression. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 8 | These results provide evidence that oltipraz suppresses 3-MC induction of CYP1A1 gene expression and that activation of C/EBPbeta by oltipraz contributes to suppression of 3-MC-inducible AhR-mediated CYP1A1 expression. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |