Title : Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.

Pub. Date : 2003 Sep 15

PMID : 12941322






1 Functional Relationships(s)
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1 Target acylsulfonamides were prepared in two steps from commercially available primary sulfonamides, which were selected based on in silico screening for their potential ability to interact with one of three binding surfaces proximal to the PTP1B catalytic site. Sulfonamides protein tyrosine phosphatase non-receptor type 1 Homo sapiens