Pub. Date : 2003
PMID : 12932292
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), has been reported to have anti-inflammatory properties and to decrease the interleukin-1 (IL-1)-induced expression of matrix metalloproteinase-1 (MMP-1) and MMP-13. | 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid | interleukin 1 alpha | Homo sapiens |
| 2 | A synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), has been reported to have anti-inflammatory properties and to decrease the interleukin-1 (IL-1)-induced expression of matrix metalloproteinase-1 (MMP-1) and MMP-13. | 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid | interleukin 1 alpha | Homo sapiens |
| 3 | To quantify the effects of CDDO on IL-1-induced MMP-1, MMP-13 and Bcl-3 expression, we stimulated the chondrosarcoma cell line SW-1353 and human primary chondrocytes with IL-1, in the presence or absence of CDDO. | 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid | interleukin 1 alpha | Homo sapiens |
| 4 | In SW-1353 cells, 300 nM CDDO significantly decreased the induction of MMP-1 and MMP-13 by IL-1. | 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid | interleukin 1 alpha | Homo sapiens |
| 5 | In human primary chondrocytes, 300 nM CDDO inhibited the induction of these genes by IL-1 to an even greater extent. | 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid | interleukin 1 alpha | Homo sapiens |
| 6 | In human primary chondrocytes, IL-1-induced Bcl-3 expression was inhibited when cells were pretreated with CDDO. | 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid | interleukin 1 alpha | Homo sapiens |
| 7 | Furthermore, overexpressed Bcl-3 could sustain the CDDO-dependent inhibition of IL-1-induced MMP-1 expression. | 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid | interleukin 1 alpha | Homo sapiens |
| 8 | Our data demonstrate that CDDO inhibits IL-1-induced MMP-1 and MMP-13 expression in human chondrocytes. | 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid | interleukin 1 alpha | Homo sapiens |
| 9 | CDDO also inhibits the expression of Bcl-3, an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression. | 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid | interleukin 1 alpha | Homo sapiens |