Title : Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3.

Pub. Date : 2003 Aug 26

PMID : 12924948






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Like MRP1, MRP3 confers resistance to etoposide (VP-16) and actively transports 17 beta-estradiol 17-(beta-D-glucuronide) (E(2)17 beta G), cysteinyl leukotriene 4 (LTC(4)), and methotrexate, although with generally lower affinity. Etoposide ATP binding cassette subfamily C member 1 Homo sapiens