Title : An orally active adenosine A1 receptor antagonist, FK838, increases renal excretion and maintains glomerular filtration rate in furosemide-resistant rats.

Pub. Date : 2003 Aug

PMID : 12922924






2 Functional Relationships(s)
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1 We tested the hypothesis that the selective adenosine A(1) receptor antagonist FK838 is orally active and causes diuresis and natriuresis, but maintains glomerular filtration rate in normal rats or in rats with furosemide resistance. Furosemide adenosine A1 receptor Rattus norvegicus
2 This study shows that the adenosine A(1) receptor antagonist FK838 is orally active and causes potent diuresis and natriuresis and maintains glomerular filtration rate in normal or furosemide-resistant rats. Furosemide adenosine A1 receptor Rattus norvegicus