Pub. Date : 2003 Aug
PMID : 12908908
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DMBA is metabolized into a DNA-attacking moiety by two phase I cytochrome P450 (CYP) enzymes CYP1A1 and CYP1B1. | 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | At the transcriptional level, DMBA induced the CYP1 enzyme expressions by stimulating the xenobiotic response element (XRE)-dependent transactivation pathway. | 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | When genistein (25 micromol/l) was co-administered with DMBA, the XRE-Luc activity the CYP1 mRNA abundances were significantly suppressed. | 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |