Title : Rationale for the chemical development of angiotensin II receptor antagonists.

Pub. Date : 1992 Dec

PMID : 1290616






1 Functional Relationships(s)
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1 The key to the discovery of nonpeptide AII-receptor antagonists with improved oral activity and duration of action resulted from replacing the carboxylic acid group with the isosteric but more lipophilic tetrazole ring. 1H-tetrazole angiotensinogen Homo sapiens