Title : Thrombin-specific inhibition by and slow cleavage of hirulog-1.

Pub. Date : 1992 May 1

PMID : 1290488






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Hirulog-1 [D-Phe-Pro-Arg-Pro-[Gly]4-desulphohirudin-(53-64) (HV1)] was designed to bind by its first four and last 12 residues to the alpha-thrombin catalytic site and anion-binding exosite for fibrin(ogen) recognition respectively, with a [Gly]4 bridge and an Arg-Pro bond at the scissional position. Proline coagulation factor II, thrombin Homo sapiens