Title : The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro.

Pub. Date : 2003 Aug 15

PMID : 12902797






4 Functional Relationships(s)
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1 Significant increases in median P-gp expression were observed following incubation with 10 microM nelfinavir (10.2 versus 6.7% P-gp-positive cells) and efavirenz (10.0 versus 6.7% P-gp-positive cells). Nelfinavir ATP binding cassette subfamily B member 1 Homo sapiens
2 Significant increases in median P-gp expression were observed following incubation with 10 microM nelfinavir (10.2 versus 6.7% P-gp-positive cells) and efavirenz (10.0 versus 6.7% P-gp-positive cells). Nelfinavir ATP binding cassette subfamily B member 1 Homo sapiens
3 Significant increases in median P-gp expression were observed following incubation with 10 microM nelfinavir (10.2 versus 6.7% P-gp-positive cells) and efavirenz (10.0 versus 6.7% P-gp-positive cells). Nelfinavir ATP binding cassette subfamily B member 1 Homo sapiens
4 However, nelfinavir, ritonavir, and lopinavir caused marked toxicity, indicating that at higher concentrations, the increase in P-gp may be at least partially related to a stress response. Nelfinavir ATP binding cassette subfamily B member 1 Homo sapiens