Title : Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK.

Pub. Date : 2003 Sep 15

PMID : 12902401






3 Functional Relationships(s)
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1 LPA-induced chemotaxis is markedly dependent on activation of PTX-sensitive heterotrimeric G-proteins, on activation of the small GTPases Ras, Rac and RhoA, and on GTPase-dependent activation of ERK. lysophosphatidic acid ras homolog family member A Homo sapiens
2 Thus, pancreatic tumor cell migration in response to LPA is essentially controlled by activation of a Gi/o-ERK pathway and requires the LPA-induced activation of Ras, Rac1 and RhoA. lysophosphatidic acid ras homolog family member A Homo sapiens
3 Thus, pancreatic tumor cell migration in response to LPA is essentially controlled by activation of a Gi/o-ERK pathway and requires the LPA-induced activation of Ras, Rac1 and RhoA. lysophosphatidic acid ras homolog family member A Homo sapiens