Title : Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes.

Pub. Date : 2003 Mar

PMID : 12899731






2 Functional Relationships(s)
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1 Nicotine also increased Fos-like immunoreactivity in dopamine target areas, an effect that was antagonized with MLA but not with DH beta E. Our data suggest that nicotine"s augmenting effect on burst firing is, indeed, due to stimulation of alpha 7 nicotinic receptors whereas other nicotinic receptors seem to induce an increase in firing frequency. Nicotine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Nicotine also increased Fos-like immunoreactivity in dopamine target areas, an effect that was antagonized with MLA but not with DH beta E. Our data suggest that nicotine"s augmenting effect on burst firing is, indeed, due to stimulation of alpha 7 nicotinic receptors whereas other nicotinic receptors seem to induce an increase in firing frequency. Nicotine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens