Pub. Date : 2003 Aug 12
PMID : 12899610
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. | Niacinamide | sirtuin 1 | Mus musculus |
| 2 | Life span regulation and inhibition of gene silencing in yeast have been linked to nicotinamide effects on Sir2 enzymes. | Niacinamide | sirtuin 1 | Mus musculus |
| 3 | The Sir2 enzymes are NAD(+)-dependent protein deacetylases that influence gene expression by forming deacetylated proteins, nicotinamide and 2"-O-acetyl-ADPR. | Niacinamide | sirtuin 1 | Mus musculus |
| 4 | Nicotinamide switching is quantitated for the Sir2s from Archeaglobus fulgidus (Sir2Af2), Saccharomyces cerevisiae (Sir2p), and mouse (Sir2alpha). | Niacinamide | sirtuin 1 | Mus musculus |
| 5 | Nicotinamide switching supports the previously proposed Sir2 catalytic mechanism and the existence of a 1"-O-peptidyl-ADPR.Sir2 intermediate. | Niacinamide | sirtuin 1 | Mus musculus |
| 6 | Nicotinamide switching supports the previously proposed Sir2 catalytic mechanism and the existence of a 1"-O-peptidyl-ADPR.Sir2 intermediate. | Niacinamide | sirtuin 1 | Mus musculus |