Title : Functional study of intracellular P-gp- and MRP1-mediated pumping of free cytosolic pirarubicin into acidic organelles in intrinsic resistant SiHa cells.

Pub. Date : 2003 Aug

PMID : 12897808






3 Functional Relationships(s)
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1 Functional study of intracellular P-gp- and MRP1-mediated pumping of free cytosolic pirarubicin into acidic organelles in intrinsic resistant SiHa cells. pirarubicin ATP binding cassette subfamily C member 1 Homo sapiens
2 We sought to determine the efficiency of the intracellular functional P-gp- and MRP1-mediated pumping of THP into acidic organelles in SiHa cells and etoposide-resistant SiHa/VP16 cells. pirarubicin ATP binding cassette subfamily C member 1 Homo sapiens
3 The functional studies of both intracellular functional P-gp- and MRP1-mediated pumping were performed by using THP in a conventional spectrofluorometer, and they demonstrated that SiHa and SiHa/VP16 cells are good models to illustrate the functional role of intracellular P-gp and MRP1 in the transport of free cytosolic drug into acidic organelles. pirarubicin ATP binding cassette subfamily C member 1 Homo sapiens