Title : NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.

Pub. Date : 2003 Aug

PMID : 12897211






1 Functional Relationships(s)
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1 Importantly, flurbiprofen and its enantiomers selectively lower Abeta42 levels in broken cell gamma-secretase assays, indicating that these compounds directly target the gamma-secretase complex that generates Abeta from APP. Flurbiprofen amyloid beta (A4) precursor protein Mus musculus