Title : HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation.

Pub. Date : 2003 Aug

PMID : 12897149






2 Functional Relationships(s)
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1 Here we show that HSP27 overexpression in various cell types enhances the degradation of ubiquitinated proteins by the 26S proteasome in response to stressful stimuli, such as etoposide or tumor necrosis factor alpha (TNF-alpha). Etoposide heat shock protein family B (small) member 1 Homo sapiens
2 HSP27 overexpression increases NF-kappaB nuclear relocalization, DNA binding, and transcriptional activity induced by etoposide, TNF-alpha, and interleukin 1beta. Etoposide heat shock protein family B (small) member 1 Homo sapiens