Title : Inhibition of cisplatin-induced ATR activity and enhanced sensitivity to cisplatin.

Pub. Date : 2003 May-Jun

PMID : 12894503






1 Functional Relationships(s)
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1 Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation. Caffeine tumor protein p53 Homo sapiens